It has been proposed that a possible mechanism through which IR induces NF-κB activation involves nuclear DNA damage and a pathway similar to the one used by camptothecin, an anti-cancer agent, that causes DNA double-stranded breaks that trigger a signaling cascade that results in the degradation of IκB⍺ and the activation of NF-κB [65]. This evidence concerns the gene NFKB1 and cancer.