Moreover, the co-administration of three different NSAIDs (celecoxib, etoricoxib, and diclofenac) was found to significantly abrogate the development of the 1,2-dimethylhydrazine dihydrochloride-induced colorectal cancer via the suppression of the NF-κB activation cascade [185]. Here, NFKB1 is linked to colorectal cancer.