While the inhibition of NF-κB had no effect on the development of transformed hepatocytes in the liver of the mice, the suppression of NF-κB was shown to promote the apoptosis of transformed hepatocytes and prevented the progression to hepatocellular carcinoma, suggesting that NF-κB plays a crucial role in cancer development [32,72]. Here, NFKB1 is linked to hepatocellular carcinoma.