One specific ligand, chemokine (C-X-C motif) ligand 12 (CXCL12), secreted by the tumours, with its concomitant receptor (C-X-C chemokine) receptor type 4 (CXCR4), which is expressed mostly in MSCs, has drawn particular interest, given its connection to the tumour-homing characteristic of MSCs as well as its contribution to MSCs’ migration [37,38]. Here, CXCL12 is linked to neoplasm.