A previous work using transfected MSCs derived from adipose tissue has shown that when these cells express a potent anti-tumour agent called TRAIL, the engineered adult stem cells (termed MSC-TRAIL) are capable of inducing apoptosis in glioblastoma (LN18) and hepatocellular carcinoma (HepG2) cells in vitro [58]. The gene discussed is TNFSF10; the disease is hepatocellular carcinoma.