Some earlier studies have hypothesized that the destruction of helper CD4+ T lymphocytes (Th2) by HIV, coupled with the significant importance of CD4+ cells in the formation of granuloma, may lead to a decreased ability of the Th2 aiming to produce proinflammatory cytokines, and hence lead to severe hepatic morbidity [33, 34]. The gene discussed is CD4; the disease is Granuloma.