Univariate analysis identified that cirrhosis (OR=1.3,95%CI:1.01-1.71), Barcelona Clinic Liver Cancer algorithm (BCLC) B-C stage (P<0.02), multiple tumor (OR=3.55,95%CI:1.12-2.1), macrovascular invasion (OR=3.55,95%CI:2.6-4.8), microvascular invasion (OR=1.9,95%CI:1.4-2.5), complications III-V (OR=1.7,95%CI: 1.14-2.54), and all the five noninvasive indexes—AST/ALT (OR=1.15,95%CI:1.07-1.23), APRI (OR=1.08,95%CI:1.02-1.13), fibrosis-4 (OR=1.04,95%CI:1.02-1.07), Lok index (OR=1.11,95%CI:1.05-1.17), and King score (OR=1.01,95%CI:1.01-1.01)—were the risk factors for overall survival. The gene discussed is GPT; the disease is liver cancer.