TLR2 and metabolic dysfunction-associated steatohepatitis: In non-alcoholic steatohepatitis, TLRs play important roles (Roh and Seki, 2013) and it has been demonstrated that TLR2-enhanced expression of Nod-like receptor protein 3 via NF-kB, promotes NLRP3-inflammasome activation in concert with saturated fatty acid in Kupffer cells (Miura et al., 2013).