Adipose PGC-1α serves as a key moderator of energy metabolism and promotes mesenchymal stem cell differentiation into brown fat adipocytes [23] and the browning of white fat to a distinct phenotype known as brite fat, which aids in the prevention of the development of metabolic syndrome and type 2 diabetes mellitus (T2DM) [24]. Here, PPARGC1A is linked to type 2 diabetes mellitus.