For this purpose, general metabolic parameters were measured concomitantly with the fatty acid (FA) composition and degree of steatosis, the oxidative stress status, and the activity of antioxidant enzymes controlled by the redox-sensitive transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) in the liver of mice subjected to HFD (60% of the total calories as fat for 12 weeks). The gene discussed is NFE2L2; the disease is steatosis.