Since curcumin exerts neuroprotective effects on PD models induced by several different environmental factors (such as 6-OHDA, MPTP, rotenone, and paraquat) and genetic factors (including α-synuclein, PINK1, DJ-1, LRRK2, and UCH-L1), our results provide additional evidence to demonstrate that treatments with curcumin have a potential as an appropriate therapy for PD related to oxidative stress. The gene discussed is UCHL1; the disease is Parkinson disease.