The activity of NF-κB has been demonstrated to be increased in endothelial cells, pericytes, and glial cells in experimental models of diabetic retinopathy, and in the retinas of diabetic patients (Romeo et al., 2002; Kowluru et al., 2003; Harada et al., 2006). This evidence concerns the gene NFKB1 and diabetic retinopathy.