Intravitreal therapies with anti-angiogenic agents, such as anti-VEGF, have improved the prognosis for diabetic macular edema (Schmidt-Erfurth et al., 2017) and anti-VEGF treatment is now the first-line therapy for diabetic macular edema involving the central macula (Thomas et al., 2013). The gene discussed is VEGFA; the disease is diabetic macular edema.