In addition, PPARα is required for the anti-inflammatory actions of PEA (Lo Verme et al., 2005), and presence of PPARα mRNA in HSCs (Miyahara et al., 2000) and suppressive effect of PPARα agonist Wy-14,643 on liver fibrosis (Ip et al., 2004) have been reported. Here, PPARA is linked to Hepatic fibrosis.