Both MAPT IVS10+16 and IVS10+16/P301S iPSCs, in conjunction with their parental isogenic wild-type cells, are useful tools to further elucidate the role of the IVS10+16 mutation, the P301S mutation, and the mechanisms underlying FTDP-17 and other tauopathies. This evidence concerns the gene MAPT and tauopathy.