Published studies about mineralocorticoid receptor antagonists (antimineralocorticoids) or (so-called) antialdosterones appeared effective in SCD and all-cause mortality prevention.21 22 54 However, in a recent systematic review,21 adverse effects (hyperkalaemia, degradation of renal function and gynaecomastia) were significantly higher in the antialdosterone-treated group compared with placebo. This evidence concerns the gene NR3C2 and Gynecomastia.