NR3C2 and Gynecomastia: In HF, antialdosterones or mineralocorticoid receptor blockers reduced SCD (subgroup analysis: 5 RCTs), all-cause mortality (subgroup analysis: 10 RCTs) and cardiovascular, all-cause and cardiovascular hospitalisation. Adverse effects (hyperkalaemia, degradation of renal function and gynaecomastia) were, however, significantly higher in the treated group compared with placebo.