Similar to our results, in a SCD cohort of adults in Holland, it was reported 5/16 (HbSS/SC & HbSβ0) had serum hepcidin levels below the normal range (measured by mass spectrometry, <1 mmol/L), and these tended to be in patients with lower ferritins and more severe anemia. The gene discussed is HAMP; the disease is anemia.