Here, our study dealt with melanoma and renal cancers, which are classified as ‘immunogenic’ tumor, based on several characteristics: incidence of spontaneous tumor regression, high level of tumor T-cell infiltration and responsiveness to immunotherapies such as interleukin 2 (IL-2) interferon alpha (IFN-α) or Anti PD1 [31]. The gene discussed is IL2; the disease is neoplasm.