These findings are similar to a study on Southern Han Chinese ancestry [21] In addition, the present study found that the T2DM risk was significantly higher in carriers with the C allele of rs780094 in GCKR. The GC genotype and dominant model of rs492594 in G6PC2 were significantly associated with a decreased risk of T2DM. Here, GCKR is linked to type 2 diabetes mellitus.