In the current study, we selected the loci of rs780094, rs2293572, rs1260326, rs492594, rs16856187 and rs13387347 from the GCKR and G6PC2 genes and evaluated the association between these loci and T2DM as well as the interaction between the GCKR and G6PC2 genes, which have never been reported either for the Chinese or the global population. Here, G6PC2 is linked to type 2 diabetes mellitus.