The most commonly prescribed therapeutic subgroups were agents acting on the renin-angiotensin system (ATC code C09: n = 514 prescriptions accounting for 10% of reference prescriptions), drugs used in diabetes (A10: n = 468, 9%), antithrombotic agents (B01: n = 409, 8%), drugs acting on the lipid metabolism (C10: n = 355, 7%) and beta blocking agents (C07: 352, 7%). The gene discussed is REN; the disease is diabetes mellitus.