In the univariate analysis by Cox regression model, age, sex, common risk factors, AST and TBil levels, tumor size, PD-L1+ TCs and the expression levels of CD133, PD-1 and PD-L2 showed no prognostic significance regarding OS or PFS (Table 1 and Additional file 1: Figure S2A-F). The gene discussed is CD274; the disease is neoplasm.