We found that PD-L1+ GBC showed a higher probability of positive PD-L2 expression in tumor tissues (83% vs. 47%, P = 0.002) and a 1.54-fold increase in the median CD8+ TIL density (PD-L1+ vs. PD-L1−: 53/field vs. 34.5/field, P = 0.029), whereas no difference in density of the CD8+ TILs existed between PD-L1+ TCs and PD-L1+ IS (47.5% vs. 57%, P = 0.568). This evidence concerns the gene CD274 and neoplasm.