Increased anxiety levels in these mice are not due to overproduction of N- or C-terminal fragment-β (NTF-β or CTF-β) of APP, as demonstrated by the observation that AppNL-G-F/NL-G-F mice exhibited anxiolytic-like behavior, whereas Tg13592 mice overexpressing CTF-β did not exhibit altered anxiety levels in comparison with their non-transgenic controls [69]. Here, APP is linked to Anxiety.