Additionally, the lysosomal markers LAMP2A and hsc70 are reduced in the substantia nigra (s.nigra) pars compacta and amygdala of PD brains compared to age-matched controls suggesting that autophagy dysregulation is concomitant with α-synuclein pathology in PD (Alvarez-Erviti et al., 2010). This evidence concerns the gene HSPA8 and Parkinson disease.