To this end we have examined levels of macroautophagy markers in post-mortem tissue from the basal ganglia of PD patients carrying the LRRK2 G2019S mutation and compared that with pathology-matched idiopathic PD and control tissue using immunoblot (IB) and quantitative reverse transcription polymerase chain reaction (qRT-PCR). Here, LRRK2 is linked to Parkinson disease.