For example, betulinic acid ameliorates experimental diabetic renal fibrosis by inhibiting the activation of NF‐kB signalling pathway.12 Oleanolic acid, the similar pentacyclic triterpene compound, exerts its therapeutic effect on tubulointerstitial fibrosis in chronic cyclosporine nephropathy.13 Another study revealed that Asiatic acid attenuates renal fibrosis by rebalancing TGF‐β/Smad signalling pathway.14 More encouragingly, previous studies of our group have found that AKBA is beneficial for vascular remodelling and fibrosis by blocking TGF‐β/Smad pathway. The gene discussed is TGFB1; the disease is renal fibrosis.