A previous publication revealed that JAK/STAT3 inhibitors could down‐regulate the miR‐181b expression in oesophageal cancer cells and it was inducible by cytokines activating STAT3.42 In colon cancer cells, to date, there is no clear answer to whether JAK can affect miR‐181b expression and whether it is induced by STAT3 activator, which needs to be further studied. This evidence concerns the gene STAT3 and malignant colon neoplasm.