Previous publications reported that STAT3 directly activated the transcription of miR‐181b‐1, a precursor of miR‐181b, leading to the increased expression of miR‐181b.19, 41, 42 Based on these findings, we proposed and explored the hypothesis that miR‐181b expression interacted with STAT3 phosphorylation in a positive feedback loop that affected the aerobic glycolysis in colon cancer cells via regulating PIAS3 expression (Figure 7). The gene discussed is STAT3; the disease is malignant colon neoplasm.