These protrusions have been shown to mediate invasion in fibronectin‐rich 3D matrix in vitro, as well as in an in vivo zebrafish model.43 Furthermore, mathematical modelling of this signalling network has revealed that a MAPK‐driven feedback loop functions to maintain Rac inhibition, and that Rab11/RCP‐driven cancer cell invasion can be disrupted by MEK inhibition.73 The gene discussed is FN1; the disease is cancer.