EGFR recycling also plays a role in invasion and metastasis, and Synaptojanin‐2 (SYNJ2), an inositol 5‐phosphatase implicated in breast cancer progression, is a key regulator of EGFR recycling to promote the formation of lamellipodia, invadopodia and metastases in vivo37 (Figure 1C). The gene discussed is EGFR; the disease is breast carcinoma.