MMP14 and cancer: While numerous proteases, membrane tethered and secreted, contribute to cancer cell invasion and metastasis, MT1‐MMP (membrane‐type‐1 matrix metalloprotease; MMP‐14) has become established as the major player in executing programmes of basement membrane and interstitial matrix invasion.92 MT1‐MMP is a transmembrane protein, and is hence subject to cycles of endocytosis and recycling that controls cell surface availability and function, perhaps by circumventing rapid inactivation by TIMP‐2 at the cells surface.92