Endosomal trafficking of the RTK c‐Met (also known as HGFR, hepatocyte growth factor receptor) via recycling endosomes controls the activation of Rac, and signalling to the cytoskeleton, to promote cancer cell migration and invasion.38 Knockdown of NHE5 (neurone‐enriched Na+/H+ exchange) increases the pH of recycling endosomes, inhibiting the recycling of the c‐MET to the plasma membrane, its delivery to the leading edge of cells and downstream signalling via Akt/ERK and Rac/Cdc42 leading to impaired directed cell migration and loss of polarity.39 The gene discussed is AKT1; the disease is cancer.