Integrin internalization is required for cancer cell invasion, for example, HAX1 (hemopoietic specific protein‐1 [HS1]‐associating protein X‐1), a ubiquitously expressed protein, directly interacts with the cytoplasmic tail of β6 integrin to control internalization of αvβ6 integrin through a clathrin‐mediated pathway to drive cancer cell invasion59 (Figure 3). This evidence concerns the gene HAX1 and cancer.