The other study (Autoimmune Diabetes Accelerator Prevention Trial, adAPT; http://adaptdiabetes.org/) involves administering metformin to healthy children who are at risk of developing type 1 diabetes as a prevention strategy; it may be beneficial to assess differences in brain Hes3 expression in detail between children and adults in order to potentially better predict unforeseen consequences. This evidence concerns the gene HES3 and type 1 diabetes mellitus.