CAB39L and neoplasm: As expected, stable knockdown of CAB39L promoted cell proliferation in MKN74 cells (Fig. 4g, P < 0.0001), whereas metformin treatment suppressed the growth of MKN74-shCAB39L cells to a greater extent as compared to MKN74-shNC cells, thereby abrogating the tumor promoting effect of CAB39L loss (Fig. 4g, P < 0.0001).