Top up-regulated DEGs in CP vs C include previously identified psoriasis-associated genes such as IL36A/G, SPRR2A/B/F, SERPINB4, S100A7A, S100A9, and IL17F while top down-regulated DEGs include SERTM1, IL6, and ADAMTS16 (Supplementary Table 1). The gene discussed is S100A7A; the disease is psoriasis.