In SP vs C, a majority (1543/2319 or 67%) of the DEGs were also differentially expressed in CP vs C, including known CP signature genes such as S100A7A, SPRR2B, IL36A/G, IL17D/F/RD/RE and SERPINB4. Keratin (KRT-) and keratin-associated protein (KRTAP-) family genes were also highly expressed in SP and in many cases, DE between SP and C, much more so than in CP or HF. The gene discussed is SERPINB4; the disease is hydrops fetalis.