Loss of bchs, the Wdfy3 homologous protein in Drosophila (Fig. 2A), results in altered endolysosomal transport, neurodegeneration and shorter lifespan19, comparable to some human neurodegenerative disorders [e.g., Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Wallerian neurodegeneration and spastic paraplegia]. Here, WDFY3 is linked to Alzheimer disease.