Deficits or pathogenic mutations in BEACH-containing proteins other than WDFY3 in humans (Fig. 2B) are associated with bipolar disorder, schizophrenia, epilepsy, ASD, and neurodegenerative diseases, such as AD, ALS and Parkinson’s disease (Fig. 2B). The gene discussed is WDFY3; the disease is amyotrophic lateral sclerosis.