The link between Wdfy3 (as an extension for autophagy) and psychiatric disorders has received support by recent findings of brain-specific downregulation of beclin1 in schizophrenic individuals44, while indirect evidence was provided by studies showing that lithium, widely used of the treatment of bipolar disorder45, along with commonly used antidepressants, induce autophagy46. Here, WDFY3 is linked to psychiatric disorder.