WDFY3 and neurodegenerative disease: When the proteomic data were analyzed against the KEGG database, pathways affected in Wdfy3 haploinsufficiency were shared with those related to neurodegenerative diseases (ALS, Parkinson’s, Huntington’s, Prion diseases) as well as those involved in vesicular transport, and dopaminergic and GABAergic synapses (Fig. 5E,F), pointing not only to decreased mitophagy, but also to defective intracellular transport (likely including mitochondria) and neuron development and/or organization.