Similar to the findings in HD patients, while there was no change total YAP (p = 0.571, Mann-Whitney U Test), there was a significant increase in pYAP (Fig. 3g,h) in the striatum of 10-month-old Htt CAG knock-in mice HdhQ111/Q111 compared to wild-type HdhQ7/Q7 (p = 0.0357, Mann-Whitney U Test). Here, HTT is linked to Huntington disease.