We also measured the expression of a known YAP target gene, cysteine-rich angiogenic inducer 61 (Cyr61)18,20,33,34, which was not represented on the array, and found a statistically significant decrease in its expression in HD cortex compared to control (p = 0.0132 Mann-Whitney U Test) (Fig. 5c). The gene discussed is CCN1; the disease is Huntington disease.