YWHAQ and Huntington disease: Our results also suggest that decreases in nuclear YAP, YAP/TEAD interaction, and transcriptional dysregulation in HD, may be due to an increase in pMST1 (active form) levels and not due to an increase in the interaction between YAP and the chaperone 14-3-3 in the presence of mHtt (Fig. 4a,b) or LATS activation in HD (Fig. 3e,f), as suggested previously26,28.