Reduced microtubule network formation in Opa1N∆ neutrophils was also observed following activation with GM-CSF/RNP ICs-Ab, GM-CSF/RNP ICs-SLE, PMA, or P. aeruginosa as compared to activated Lyz2Cre/Cre control neutrophils (Supplementary Fig. 4c). This evidence concerns the gene RNPC3 and systemic lupus erythematosus.