MKI67 and neuroblastoma: Because MKI67 is another gene localized close to the enhancer, we first analyzed the published Hi-C data sets38 to determine whether the MKI67 gene localized in the same topologically associating domain (TAD) with MGMT. We found that MIK67 resided in the same TAD as MGMT and the enhancer in neuroblastoma cells (Fig. 6b) and localized at the left boundary of the TAD domain-containing MGMT in cortical and subcortical plate cells (Fig. 6c).