MGMT and neoplasm: Although the levels of H3K4me1 and H3K27ac enrichment at the K-M enhancer locus do not correlate with MGMT expression in GBM46 line, activation of the enhancers in two other MGMT promoter-methylated PDX lines correlates with high levels of MGMT expression, suggesting that enhancer activation is one explanation for the discordance between MGMT promoter methylation and gene expression in both primary and recurrent tumor lines.