Selective conditional ablation of FAP+ HO-1+ TAMs, or pharmacological inhibition of their HO-1 activity, results in a cessation of tumour growth in subcutaneously implanted immunogenic LL2/OVA tumours, suggesting that these cells are a non-redundant population within the tumour microenvironment, and that HO-1 expression might represent a key effector molecule in their pro-tumorigenic functions3. This evidence concerns the gene HMOX1 and neoplasm.