Of all the 139 T2D-associated loci identified in our meta-analysis, 16 and 25 were significant in insulin secretion and sensitivity GWAS, respectively, from the MAGIC consortium24,25 (see URLs section) after correcting for multiple tests (i.e., 0.05/139), with only 1 locus showing significant associations with both insulin secretion and sensitivity. Here, INS is linked to type 2 diabetes mellitus.