A genetic variant near ATP5G1 exerts an effect on T2D by increasing the DNAm levels of the promoters for ATP5G1 and UBE2Z; this decreases the binding affinity of the transcription factors that recruit RNA polymerase, resulting in down-regulation of gene expression and ultimately leading to an increase in T2D risk (Supplementary Fig. 14b). The gene discussed is ATP5MC1; the disease is type 2 diabetes mellitus.