Interestingly, IL-23R rs11209026 and ERAP1 rs27524 (intronic) were associated with pediatric onset psoriasis (<18 years) in HLA-C*06 positive individuals [80], whilst additional investigation revealed the association of another ERAP1 SNP, rs26653 (R127P P=0.00006), which was confined to disease onset after puberty (10–20 years), but is not dependent on HLA-C*06 expression [81]. Here, HLA-C is linked to psoriasis.