This is very important because intrarenal ANG II content in ANG II-dependent models of hypertension results from both AT1 receptor-mediated uptake of circulating ANG II and de novo intrarenal ANG II formation [66]; this is also the case with the Cyp1a1-Ren-2 transgenic rats after induction of malignant hypertension [31,35,36]. The gene discussed is CYP1A1; the disease is malignant hypertension.