Notwithstanding the above compelling evidence, one must, however, be aware that, as reported by us and others malignant hypertension in the Cyp1a1-Ren-2 transgenic rats is characterized by a distinct intrarenal augmentation of the hypertensogenic axis of the RAS, as reflected by a marked increase in kidney ANG II concentration [31–36]. The gene discussed is AGT; the disease is malignant hypertension.