Therefore, the measured intrarenal deficiency of 20-HETE (reflecting mostly decreased intratubular content) and the consequent elimination of 20-HETE-mediated inhibition of tubular reabsorption may further promote the development of ANG II-dependent malignant hypertension in this model, which would agree with our recent report on the beneficial effects of fenofibrate [40]. Here, AGT is linked to malignant hypertension.