Increased SETDB1 mRNA levels and decreased TP53 mRNA levels were observed in NSCLC tissues than in adjacent normal lung tissues (Figure 5A,B), and the Pearson correlation analysis further showed that their mRNA levels were negatively correlated in NSCLC samples (n=30, r = −0.623, P=0.0002. This evidence concerns the gene TP53 and non-small cell lung carcinoma.