Moreover, we found that CD184− HE was restricted in the CD31med/loCD34med/lo population, but CD184+ AVE existed in both the CD31med/loCD34med/lo and CD31hiCD34hi populations, indicating that the CD34/CD31 threshold will influence the specification of vascular progenitors, and CD31med/loCD34med/lo is a signature for HE. The gene discussed is CXCR4; the disease is hereditary elliptocytosis.