On the other hand, Okata and colleagues successfully showed that the LQTS3 phenotype is recapitulated by a SCN5A sodium channel mutation that was maintained in hiPSCs derived from a Brugada syndrome patient, yet the Brugada syndrome phenotype was not displayed until SCN5B expression, increased due to the embryonic nature of these cells, and was opposed by knock-down [246]. The gene discussed is SCN5A; the disease is Brugada syndrome.