Therefore, the differentiation-inducing therapy by retinoic acid treatment improves the overall survival of the patients with N-Myc-amplified neuroblastomas, and all-trans retinoic acid (ATRA) treatment abrogated the mutual transcriptional regulations between N-Myc, NCYM, and Oct4, all of which induce the differentiation of neuroblastoma precursor cells [86, 92, 93]. Here, POU5F1 is linked to neuroblastoma.