It has been very recently reported that c-Myc contributes to the metabolic reprogramming of pyrimidine synthesis mediated by the up-regulation of CAD gene encoding carbamoyl-phosphate synthetase 2, UMPS gene encoding uridine monophosphate synthetase, and CTPS gene encoding cytidine triphosphate synthase in colon adenocarcinoma cells [162]. Here, UMPS is linked to colon adenocarcinoma.