FBW7 depletion in BM-derived stromal cells (BMSCs) results in the accumulation of Notch-1 intracellular domain (NICD1) and increased secretion of CCL2, which in turn promotes recruitment of monocytic myeloid-derived suppressor cells (Mo-MDSCs) and tumor-associated macrophages (TAMs). The gene discussed is NOTCH1; the disease is neoplasm.