SLC7A11 and neoplasm: xCT/SLC7A11 transporter uptakes cystine in exchange for glutamine, which is essential for reduced form of glutathione (GSH) synthesis to reduce reactive oxygen species (ROS) in the tumor microenvironment [74, 117–120], while ASCT2/SLC1A5 transporter uptakes glutamine in a collaborative manner with xCT/SLC7A11 [101, 121].