SLC1A5 and triple-negative breast carcinoma: For a typical instance, triple-negative breast cancer (TNBC) lacking in the expression of estrogen receptor, progesterone receptor, and the tyrosine kinase receptor HER2/EGFR2, exhibits the significant dependence on the glutamine metabolism due to the coordination between the amino acid transporters such as xCT/SLC7A11 and ASCT2/SLC1A5 [100, 116].