NOTCH1 and acute lymphoblastic leukemia: Mechanistically, leukemic cells in FBW7-deficient mice fail to exhibit the FBW7-dependent degradation of Notch-1 and c-Myc, which is why the high expression level of Notch-1 and c-Myc in FBW7-deficient BM cells is regarded as responsible for T-ALL development [194, 195].