Our results showed –first- that Alcohol and obesity were the clinical parameters significantly associated with G894 T eNOS distribution (P = 0.009 and 0.02 respectively); a tendency to a statistically significant association was also found with ‘Age’, Physical activity’ and ‘Personal history of cardiovascular disease’ (P = 0.07, 0.05 and 0.07 respevtively) (Table 1). Here, NOS3 is linked to obesity due to melanocortin 4 receptor deficiency.