By binding to SSc circulating fibrocytes expressing CD86, CTLA4-Ig might interfere with their APC activity and could likely prevent the activation of T lymphocytes, as already demonstrated for other cellular targets (dendritic cells, B lymphocytes, macrophages, osteoclasts, endothelial cells) [21, 24, 34–37]. Here, CTLA4 is linked to systemic sclerosis.