Different data show that genetic metabolism errors are responsible for some of CRMO syndromes [7, 16], for example, the PSTPIP1 gene is associated with pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome [7] as well as defects in LPIN2 result in Majeed syndrome [16]. Here, PSTPIP1 is linked to pyoderma gangrenosum.