APOA5 and hepatocellular carcinoma: Using transfected doxycycline-inducible McA-RH7777 rat hepatoma cell line, Blade et al. found that apoA5 treatment could inhibit TG secretion, increase intracellular TG concentration and reduce VLDL particle; when stably transfected McA-RH7777 cells were treated with oleic acid, the resulting increased in TG synthesis caused a reduction in apoA5 secretion, which has been considered as a reciprocal increase in cell-associated apoA5.