The prevalence of the APOA5*2 haplotype (containing the minor allele of -1131 T > C, IVS3 + G476A and c.1259 T > C SNPs together) was 15.5% in obese children and 5.80% in the controls, and this haplotype confers susceptibility for development of obesity [43]. This evidence concerns the gene APOA5 and obesity due to melanocortin 4 receptor deficiency.