They found that C-allele of APOA5 SNPs was associated with higher HDL and the GC haplotype, which was composed of the G-allele of APOA1 SNPs and the C-allele of APOA5 SNPs (summarized in Table 1), was significantly associated with obesity, with higher glycated hemoglobin, and fasting glucose [47]. Here, APOA5 is linked to obesity due to melanocortin 4 receptor deficiency.