BRCA2 and Friedreich ataxia: The following cell lines were used: i) BJ, wild-type human fibroblasts; ii) FANCA−/− +Vector, FA patient fibroblasts which have defective DNA crosslink repair due to biallelic mutations in the FANCA gene; iii) FANCA−/− +WT-FANCA, the same FA fibroblasts transfected with a FANCA gene, which restores their DNA crosslink repair; iv) FANCD1−/- FA patient fibroblasts which have defective DNA crosslink repair due to biallelic mutations in the FANCD1/BRCA2 gene.