In addition, administration of a neutralizing anti-CCL2 antibody reduced ankle swelling in the rat CIA model [23], CCL3-deficient mice exhibited milder arthritis induced by an anti-type II collagen mAb [24] and treatment with polyclonal anti-CCL5 antibody ameliorated adjuvant-induced arthritis in rats [25]. Here, CCL2 is linked to arthritic joint disease.