Histological evaluation revealed a substantial reduction of leucocyte infiltration into synovial tissues, synovial hyperplasia and joint erosion by anti-CCL3 treated mice vs controls (Fig. 4B and C), resulting in a significantly reduced arthritis index in the wrist (P < 0.01) and elbow (P < 0.05) joint. The gene discussed is CCL3; the disease is arthritic joint disease.