The discovery ofHRG, along with other genotypes such as PLA2R (membranous glomerulonephritis),ADAMTS13 (thrombotic thrombocytopenic purpura), and suPAR (focal segmentalglomerulosclerosis), suggests that the era of "Precise Medicine" has also reachedNephrology, with the identification of specific genetic mutations causing diseaseswith high prevalence. Here, PLA2R1 is linked to thrombotic thrombocytopenic purpura.