Although the Zp-V3 variant has been shown to be over-represented in type 1 EBV genomes isolated from NPCs in China, and in AIDs-related lymphomas in Italy (relative to its frequency in non-malignant samples obtained from humans living in the same geographic regions [22,23]), whether the Zp-V3 variant is over-represented in type 1 EBV genomes in Burkitt lymphomas (BLs) is not yet known. This evidence concerns the gene HEPHL1 and Burkitt lymphoma.