Nevertheless, since we show here that the Zp-V3 promoter variant produces more lytic EBV reactivation than the Zp-P variant in response to BCR activation, and all type 2 EBV strains sequenced to date contain the Zp-V3 version of the promoter, it is interesting to speculate that increased lytic reactivation by type 2 EBV strains may partially compensate for the less transforming phenotype (at least in vitro) in terms of the ability of type 2 strains to promote Burkitt lymphomas. The gene discussed is BCR; the disease is Burkitt lymphoma.