Consistent with previous reports, EBV gB is retained in the ER and nuclear envelope and barely detectable on the plasma membrane (PM) [19,25] in both NPC and oral cancer cell lines (S5B and S5C Fig), while FBXO2 is a cytoplasmic protein (S5B and S5D Fig). This evidence concerns the gene FBXO2 and lip and oral cavity carcinoma.