Interestingly, cells originating from the nasopharynx epithelium, including six NPC cell lines, two primary NPC cell lines, and two immortalized nasopharyngeal epithelial (NPE) cell lines, all expressed considerable amounts of FBXO2, with the exception of HK1, which is the only well-differentiated squamous carcinoma cell line and is less representative for NPC [38]. This evidence concerns the gene FBXO2 and squamous cell carcinoma.