FBXO2 and non-Hodgkin lymphoma: On the other side, none of the B cell lines examined expressed FBXO2, including the EBV-negative non-Hodgkin's lymphoma B cell lines DoHH2 and SU-DHL-2, the EBV-positive Burkitt's lymphoma (BL) cell lines Raji and Akata and an EBV-negative Akata cell line, and the induction of EBV into lytic replication by IgG crosslinking did not induce FBXO2 expression in Akata-EBV+ cells (Fig 2A).