Similar to a recent finding on the p-AKT level in the spleen of murine CLP-induced sepsis [31], we also found that sepsis significantly downregulated p-AKT level in the spleen, while the mice treated with human ghrelin significantly increased p-AKT level by 21% as compared to the vehicle-treated septic mice (Fig 8). This evidence concerns the gene AKT1 and Sepsis.