Results from the prospective ongoing NCT02521051 trial, which aims to evaluate the role of alectinib and bevacizumab, and the ASCEND-7 (NCT02336451) trial, designed to assess the efficacy of ceritinib in ALK-positive NSCLC patients with BMs or leptomeningitis who are progressing on crizotinib and who are not treated with radiotherapy, will help to better define the optimal sequence of brain radiation and systemic ALK inhibition. This evidence concerns the gene ALK and non-small cell lung carcinoma.