The activation of p65 NF-κB further promoted transcription of both ATP-binding cassette subfamily B member 1 (ABCB1) and CCL20, which sequentially increased extracellular efflux of taxane and enhanced CCL20 effect via a positive feedback loop, leading to the taxane-resistance of TNBCs and promoting breast cancer progression with worse prognosis. The gene discussed is NFKB1; the disease is breast cancer.