Protein misfolding and aggregation is closely associated with the development of many neurodegenerative disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD).1 In AD, the protein tau is deposited in intracellular inclusions,2 while the amyloid beta (Aβ) peptide is in extracellular plaques. The gene discussed is MAPT; the disease is Parkinson disease.